The novel subtype of G protein β-subunit found in fish retina
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High glucose condition down-regulates the inhibitory G-protein subunit, Gαi, in pheochromocytoma PC12 cells
Introduction: G-proteins have an important role in the cell signaling of numerous receptors. The situation of G-proteins in health and disease and their critical role in the development of diabetic side effects is an interested scientific field. Here, the changes in the expression of G-protein subunits (Gαi, Gαs and Gβ) were evaluated in hyperglycemic situation of PC12 cells as...
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15 صفحه اولFidelity of G protein b-subunit association by the G protein g-subunit-like domains of RGS6, RGS7, and RGS11
Several regulators of G protein signaling (RGS) proteins contain a G protein g-subunit-like (GGL) domain, which, as we have shown, binds to Gb5 subunits. Here, we extend our original findings by describing another GGLdomain-containing RGS, human RGS6. When RGS6 is coexpressed with different Gb subunits, only RGS6 and Gb5 interact. The expression of mRNA for RGS6 and Gb5 in human tissues overlap...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1999
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.39.s75_3